Dostinex 0.5 mg Tablets –


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Dostinex 0.5 mg Tablets

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Dostinex Tablets USP comprise Dostinex, USP, a dopamine receptor agonist. The chemical identify for Dostinex, USP is 1-[(6-Allylergolin-8β-yl)-carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea and has the next structural formulation:

  • C26H37N5O2 M.W. 451.6

Dostinex, USP is a white powder soluble in ethyl alcohol, chloroform, and N, N-dimethylformamide (DMF); barely soluble in 0.1N hydrochloric acid; very barely soluble in n-hexane; and insoluble in water.

Every Dostinex Pill USP, for oral administration, accommodates 0.5 mg of Dostinex, USP and has the next inactive substances: anhydrous lactose and leucine.

Dostinex USP structural formulation


Mechanism of Motion

The secretion of prolactin by the anterior pituitary is especially underneath hypothalamic inhibitory management, doubtless exerted by means of launch of dopamine by tuberoinfundibular neurons. Dostinex is a long-acting dopamine receptor agonist with a excessive affinity for D2 receptors. Outcomes of in vitro research display that Dostinex exerts a direct inhibitory impact on the secretion of prolactin by rat pituitary lactotrophs. Dostinex decreased serum prolactin ranges in reserpinized rats. Receptor-binding research point out that Dostinex has low affinity for dopamine D1, α1– and α2-adrenergic, and 5-HT1– and 5-HT2-serotonin receptors.


The advisable dosage of Dostinex tablets for initiation of remedy is 0.25 mg twice every week. Dosage could also be elevated by 0.25 mg twice weekly as much as a dosage of 1 mg twice every week in keeping with the affected person’s serum prolactin degree. Earlier than initiating remedy, cardiovascular analysis must be carried out and echocardiography must be thought of to evaluate for valvular illness.

Dosage will increase shouldn’t happen extra quickly than each four weeks, in order that the doctor can assess the affected person’s response to every dosage degree. If the affected person doesn’t reply adequately, and no extra profit is noticed with greater doses, the bottom dose that achieved maximal response must be used and different therapeutic approaches thought of. Sufferers receiving long-term remedy with Dostinex ought to endure periodic evaluation of their cardiac standing and echocardiography must be thought of.

After a traditional serum prolactin degree has been maintained for six months, Dostinex could also be discontinued, with periodic monitoring of the serum prolactin degree to find out whether or not or when remedy with Dostinex must be reinstituted. The sturdiness of efficacy past 24 months of remedy with Dostinex has not been established.

Additional information

Weight 0.25 kg
Dimensions 8 × 6 × 8 cm


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